O44: WOUND HEALING INFLAMMATORY MARKERS PREDICT PROGNOSIS AND SURVIVAL IN EARLY BREAST CANCER

Abstract Introduction Cancer is likened to a non-healing wound. There limited evidence on the expression of wound healing tissue inflammatory markers, CD68(pan-macrophage marker), HO-1(tumour cell marker) and FAP(cancer-associated fibroblast in human breast cancer. Method In 201 invasive cancer 58 DCIS patients, CD68+TAM expression, tumour HO-1 FAP quantified by immunohistochemistry(dichotomised: high/present vs low/absent), was correlated with factors (grade, proliferation(Ki67), ER, HER2); demographic factors, behavioural (smoking, alcohol) survival status(DFS, OS) Result High CD68+macrophage increased cancer, compared DCIS, normal distant from tumour(59%,41%and 6% respectively; p<0.001).In cancer,CD68+TAM increasing grade(Grade 1:42%, Grade 2:58%, 3:72%; p=0.006), high Ki67(71%vs.47%; p=0.004), ER negativity(79.4%vs.55.4%; p=0.01) HER2(HER2 positive 81.8% vs. HER2 negative 56.3%; p=0.03). higher low/intermediate grade DCIS(44% % 31% p=0.52). patients who self-reported alcohol intake(non-drinker 43% drinker 62%; p=0.01). associated shorter DFS(HR:3.22,p=0.027) OS(HR:2.86,p=0.029).FAP longer DFS (HR:0.296,p=0.029) OS (HR:0.271,p=0.008). Conclusion Tumour inflammation as assessed shows utility identifying aggressive sub-types. The association reported between density intake suggests possible mechanism for risk factor prognostic value demonstrated here functional role these markers HO-1:Heme-oxygenase-1; FAP:Fibroblast activation protein; TAM:Tumour macrophage; DCIS: Ductal carcinoma situ Take-home message Wound pathways may be implicated early development